A Processed Grain Food Inhibits Hepatic Injury in Endotoxemic Rats
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概要
- 論文の詳細を見る
Although various antioxidants have been tested as therapeutics for endotoxemic subjects, the results of their efficacy are conflicting. Antioxidant biofactor (AOB) is a unique processed grain food that exhibits strong antioxidant activity (Minamiyama et al, J Nutr Sci Vitaminol, 40: 467-477, 1994). The present study was carried out to test the effect of AOB on hepatic injury in rats induced by lipopolysaccharide (LPS). Intravenous administration of LPS induced liver injury with a concomitant increase in hepatic generation of nitric oxide (NO) and 4-hydroxy-2nonenal (HNE) modified proteins in the control group. The administration of AOB significantly inhibited the LPS-induced hepatic injury and generation of HNE-modified proteins and increased the survival rate of endotoxemic rats without affecting NO generation and plasma levels of tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ). AOB scavenged superoxide radicals without affecting NO production by LPS-stimulated macrophage cell line J 774.2 cells. AOB also inhibited lipid peroxidation induced by LPS in the cells. These results suggested that AOB might scavenge superoxide radicals and decrease toxic metabolites including HNE, thereby inhibiting liver injury in endotoxemic rats.
- 財団法人 学会誌刊行センターの論文
著者
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Minamiyama Yukiko
Department Of Hepato-biliary-pancreatic Surgery Osaka City University Graduate School Of Medicine
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Takemura Shigekazu
Department Of Hepato-biliary-pancreatic Surgery Osaka City University Graduate School Of Medicine
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Inoue Masayasu
Department Of Biochemistry & Molecular Pathology Osaka City University Medical School
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Sato Eisuke
Department Of Biochemistry And Molecular Pathology
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Tanimoto Yuko
Department Of Orthodontics And Dentofacial Orthopedics Okayama University Graduate School Of Medicin
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Minamiyama Yukiko
Department Of Anti-aging Food Sciences Graduate School Of Medicine Dentistry And Pharmaceutical Scie
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Minamiyama Yukiko
Department Of Anti-aging Food Sciences Graduate School Of Medicine Dentistry And Pharmaceutical Scie
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TOYOKUNI Shinya
Pathology and Biology of Diseases, Graduate School of Medicine, Kyoto University
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INOUE Masayasu
Departments of Biochemistry Osaka City University Medical School
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SATO Eisuke
Department of Applied Molecular Bioscience, Graduate School of Medicine, Yamaguchi University
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SATO Eisuke
Departments of Biochemistry Osaka City University Medical School
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TANIMOTO Yuko
Departments of Biochemistry Osaka City University Medical School
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MINAMIYAMA Yukiko
Departments of Biochemistry Osaka City University Medical School
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