Clinical study on the effect of Vitamin B compounds on immunological responses. Part 1.

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Recently several investigations have reported that Vitamin B compounds have an immunomodulate effect. In this paper, the effects of Vit. B compounds consisting of B1, B6 and B12 (Vitamedin®) on the immunological response were investigated in patients with oral cancer. Five patients with oral cancer (Stage II-IV) who received chemotherapy (PEP, CDDP and MMC) were eligible for this study, and Vit. B compounds were administered at a daily dose of 2 vials during chemotherapy and/or other periods. Lymphocyte blastoid transformation tests with PHA and delayed hypersensitivity (Skin reaction) with PPD and Su-PS were evaluated for monitoring the cell-mediated immunity. The rate of T-cells, B-cells and serum immunoglobulins (IgG, IgA, and IgM) was also measured. Serum immunoglobulins tended to decrease after chemotherapy, and this tendency was prevented and improved by the administration of Vit. B compounds. Delayed skin test (PPD, Su-PS) and lymphocyte blastoid transformation tests with PHA were generaly increased by the administration of Vit. B compounds. The rate of B-cells tended to increase, too. As a result, it is suggested that the improvement of humoral and cell-mediated immunity was caused by the immunomodurate effect of Vit. B compounds consisting of B1, B6 and B12, and the administration of Vit. B compounds for chemotherapy was useful for immunological response in the patients with oral cancer.
社団法人日本口腔外科学会の論文