長期透析療法患者膨隆顎骨の赤外分光法による組成解析

概要

論文の詳細を見る
In the oral-maxillofacial region, there are many reports concerning on bone diseases, so called renal osteodystrophy. We have experienced a chronic renal failure patient with remarkable enlargement of jaw bones. This patient has been treated with hemodialysis therapy for over 10 years complicated by secondary hyperparathyroidism. This paper reports the clinical findings and the components of jaw bone analysed by Fourier transform infrared spectroscopy (FT-IR). In this study, we used synthetic apatites and alveolar bone of a patient, who did not have metabolic bone disease, as controls. The transmission spectra of the patients alveolar bone was compared to those of the controls. Moreover, the subtraction spectra studies were carried out between the patients sample and the controls. Pathohistological findings were widely bone absorption replaced by fibrous tissues. The transmission spectra of the patients sample was different from those of the hydroxyapatite and carbonate-containing apatite. However, the absorption intensity of the patients sample in the area of PO3-4 and CO2-3 were similar to, but somewhat stronger than, that of the cortical bone of the control. These differences among the samples were confirmed by the analysis of subtraction spectra. These findings suggested that the alveolar bone of the patient was formed by the fibrous and osseous tissues with hyper-calcification.