Oral squamous cell carcinoma with eosinophilic infiltration.

概要

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Blood eosinophil and eosinophilic infiltration of tumor tissues in patients with oral squamous cell carcinoma and no allergic diseases were investigated. The patients with blood eosinophilia (>6.0%) were 10/85 (11.8%), and the patients showing increase of % blood eosinophil more than 5% as compared to that of the preirradiated state within 2 months postrirradiation were 20/72 (27.8%). On the other hand, high grade eosinophilic infiltration (>50 cells in 400 field) to tumor tissues was observed in 7/76 of biopsy specimens and in 3/50 of operated materials.<BR>In a case with eosinophilia and eosinophilic infiltration of both biopsy and operated materials, the correlation of eosinophilia with tumor growth and regression was strongly suggested.<BR>These results indicate that although eosinophilia is induced by oral cancer as well as irradiation, tumor cells may produce an eosinophil chemotactic factor (ECF) in tumor-induced eosinophilia.
社団法人日本口腔外科学会の論文