Latamoxefのヒト歯肉, 顎骨および血中濃度の検討

概要

論文の詳細を見る
Transport of LMOX administered by intravenous drip infusion (1g/30 minutes) to the bone and soft tissues as well as the pus in the upper and lower jaws was examined in 77 oral surgery cases. The serum concentration of the agent was 102.2μg/ml after 30 minutes, 43.9μg/ml after 1 hour, and 13.1μg/ml after 4 hours. The maximum tissue concentrations were 17.6μg/g in the upper jaw bone, 9.8μg/g in the lower jaw bone, 37.4μg/g in the upper jaw soft tissue, 20.1μg/g in the lower jaw soft tissue, and 40.2μg/g in the pus. These concentrations relative to the serum concentration ranged from 20-50% despite a considerable variation among sites. As for the intraosseous concentration and MIC 80 values of bacteria, which are the most important indexes, the former exceeded the latter in most bacterial strains examined except P. aeruginosa. These results indicate that LMOX is a useful drug in oral surgery.