A clinicopathological study of oral squamous cell carcinomas. Analysis of proliferating activity by immunohistochemical technique monoclonal PCNA antibody.:Analysis of proliferating activity by immunohistochemical technique monoclonal PCNA antibody

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A clinicopathological study was carried out by immunohistochemically analyzing proliferating activity using a monoclonal PCNA antibody in 56 cases of oral squamous cell carcinoma. Specimens were obtained before treatment, fixed in 10% formalin and embedded in paraffin. Immunostaining was performed by the streptoavidin-biotin-peroxidase complex method with monoclonal mouse anti-human PCNA antibody. PCNA positive cell index was calculated as the percentage of PCNA positive cells/1, 000 tumor cells. These indices were compared with clinicopathological features. The following rasults were obtained:<BR>1. The mean±S.E. of PCNA positive cell index in the 56 cases was 32. 4 ± 9.8%, <BR>2. PCNA positive cell index was correlated with the macroscopic growth pattern, stage and degree of cellular atypism.<BR>3. PCNA positive cell index was not correlated with the degree of histological differentiation and pattern of invasion.
社団法人日本口腔外科学会の論文