A case of mucous membrane pemphigoid in the gingiva.

概要

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Mucous membrane pemphigoid is a vesiculobullous disease of unknown etiology which is relatively uncommon. This disease is diagnosed on the basis of histopathologic and immunofluorescence studies in biopsy of the oral mucosa. A 62-year-old woman with erosion on the gingiva visited our clinic. Oral examination revealed erosion on the gingiva. Histopathological features showed a definite subepithelial vesicle formation and t nonspecific chronic inflammatory infiltrate in the connective tissue. The entire epithelium was intact and no evidence of acantholysis was found. The results of direct immunofluorescent staining demonstrated a linear basement membrane zone pattern with IgG and C3. The diagnosis of mucous membrane pemphigoid was established. Although the oral lesion has not healed completely after 2 years of observation, the patient's symptoms were alleviated by topical steroid therapy and by brushing after scaling. The clinical and histopathological characteristics of mucosal pemphigoid were discussed.
社団法人日本口腔外科学会の論文