The relation between peripheral blood lymphocyte and its subpopulation in the patient with malignant tumor of head and neck region.
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In 40 patients diagnosed as having head and neck region malignant tumors, we studied the changes of peripheral blood lymphocyte and its subpopulation using OK and T series monoclonal antibody.<BR>We divided the patients into three classes: good prognostic cases (13 cases), cancerous cases (16 cases) and death cases (11 cases).<BR>Peripheral blood lymphocyte showed tendencies of decreases in the following order: good prognostic cases, cancerous cases and death cases (p<0.01).<BR>In death cases, 8 cases (73%). showed that the number of peripheral blood lymphocyte was under 1, 000/mm<SUP>3</SUP>.<BR>We found no significant correlation in both the percentage and the number of OKT-1<SUP>+</SUP> & NKH-1<SUP>+</SUP>.<BR>The percentages of OKT-3<SUP>+</SUP> & OKT-8<SUP>+</SUP> showed tendencies of increases in the following order: good prognostic cases, cancerous cases and death cases.<BR>But, the number of OKT-3<SUP>+</SUP>, decreased in the following order: good prognostic cases, cancerous cases and death cases (p<0.05). The number of OKT-8<SUP>+</SUP>, showed the same order of decreases as above.<BR>The percent and the number of OKT-4<SUP>+</SUP>, decreased in the following: good prognostic cases, cancerous cases and death cases (p<0.05, p<0.01).<BR>The "T helper/T suppressor" ratio (OKT-4<SUP>+</SUP>/OKT-8<SUP>+</SUP>) showed significant increases in the following order: death cases, cancerous cases and good prognostic cases (p<0.01).<BR>We considered most probable that the decline of the immunological capacity in head and neck region malignant tumor patients were caused by the decreases in the number of OKT-4<SUP>+</SUP>.
- 社団法人 日本口腔外科学会の論文
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