低出力炭酸ガスレーザーの結合組織代謝に及ぼす影響について

概要

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Skin abrasion wounds of the guinea pig back were irradiated by a CO2 laser beam (4.5 J/cm2) and the collagen and DNA content and type I and III collagenase activity in the wound tissue were determined to investigate biochemical effects on the metabolism of connective tissue components after low power CO2 laser irradiation. The results of this experiment yielded three conclusions: 1. The hydroxyproline content of irradiated skin 14 days after inflicting the skin abrasion was higher than that of non-irradiated skin. 2. The enzyme activities of type I and II collagenase in irradiated skin were higher than those in non-irradiated skin 5 and 7 days after making the skin abrasion. 3. As there was no apparent increase in tissue temperature at the irradiation conditions of this experiment (4.5 J/cm2), the thermal and photochemical effects of low power CO2 laser irradiation (10.6μm) were ruled out. An other, new, biochemical effect was most liked involved in the observed phenomena.