Brevibacterium ammoniagenesのリジン要求変異株によるα,ε-ジアミノピメリン酸の蓄積

概要

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Some lysine auxotrophic mutants of Brevibacterium ammoniagenes were found to accumulate α, ε-diaminopimelic acid (DAP) in the culture medium. The culture conditions for DAP production by these strains were investigated. In synthetic media, lysine concentration of the culture medium remarkably affected DAP accumulation. The DAP accumulation was maximum at a suboptimum concentration of lysine for the growth of the microorganism. Accumulation of DAP remarkably increased by the supplementation of the medium with aspartic acid, glutamic acid, succinic acid, malic acid, or formic acid, some of which were known to be the precursors of DAP biosynthesis. DAP production reached to the level of 7.1mg per milliliter with the medium containing acid hydrolysates of the cells of glutamic acid producing bacterium and lysine.
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