Late dermatopathy after proton beam radiation for skin malignant tumor.

概要

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Four of the 24 patients with malignant skin tumors treated by proton beams developed ulcer in the radiation field 6 months to 2 years after the irradiation. To determine adequate fractionation regimen, we plott on logT-logD and logN-logD planes the total dose (D), the overall treatment time (T), and the number of fractions (N) of 16 patients, whose radiation field could be observed for longer than 6 months. The regression curves of the 4 patients who developed ulcer were regarded isoeffective as to radiation-related skin damage in late phase. The fractionation schedules should be chosen in the area under the isoeffect curves, especially when skin tumors are treated by proton beams alone. And, this is an important point to be considered, when we seek the appropriate dose-fractionation of proton irradiation to improve local control rate of malignant melanoma.
日本皮膚悪性腫瘍学会の論文