悪性黒色腫に対する陽子線療法の試みについて
スポンサーリンク
概要
- 論文の詳細を見る
In 7 patients the primary lesion of malignant melanoma was treated with proton beams in Proton Medical Research Center, University of Tsukuba. Four cases were male and the other 3 were female. Five cases were acral lentiginous melanomas and the other 2 were superficial spreading melanomas. Two cases received 3 to 8Gy fractions administrated 15 or 16 times in 24 or 44 days to a total dose of 90 or 91Gy. The other patients received even higher single doses than them, i.e. large fraction radiotherapy. They received 10 to 13Gy fractions administrated 7 to 11 times in 9 to 18 days to a total dose of 91 to 110Gy. Clinically the tumor reacted to the irradiation and in 6 cases showed partial regression of the size with erosive reaction, and in one case showed complete regression with complete healing of moist desquamation. Histological examinations were performed in 4 cases and they showed many melanoma cells degenerated. Electromicroscopic examination revealed that the organelle and the nucleus highly degenerated. Results indicated good local effects were obtained by proton beams, although additional modalities were requested to manage the remaining tumors.Malignant melanoma is considered unresponsive to conventional radiation therapy in part due to a large shoulder on the radiation survival curve and higher dose fractions might be beneficial. The superior dose distribution of proton beams allows high-dose exposure to the target area with lesser dose to the surrounding normal tissues. And it enables one to treat malignant melanomas with as high single doses as 10 Gy like in the 5 cases, expecting that repair process of melanoma cells would be overcome. It is postulated that proton therapy should allow malignant melanoma to be treated with even higher doses resulting in improved local control rates.
著者
関連論文
- 182 アトピー性疾患患者におけるIL-13の機能性遺伝子多型の解析
- ハンセン病患者の2例
- バージャー病の下腿潰瘍に生じ間葉系腫瘍との鑑別が困難であった低分化有棘細胞癌の1例
- ステップワイズ重回帰分析を用いた悪性黒色腫の予後因子の解析
- N-Butyl-N-(4-Hydroxybutyl) nitrosamineによるマウス膀胱癌の進展に対する陽子線照射の効果
- 血管肉腫の治療
- 筑波大学における陽子線治療の初期治療成績
- ケラチンの免疫組織化学染色パターンが Bulge Area に一致した Trichoblastic Fibroma
- 特別講演 7 消化器癌に対する陽子線照射療法(第38回日本消化器外科学会総会)
- 悪性黒色腫に対する陽子線療法の試みについて
- 比例ハザードモデルを用いた悪性黒色腫の予後因子の検討
- Subtotal integumentectomy を施行した in-transit 転移を有する悪性黒色腫の4例
- Late phase II clinical test of irinotecan hydrochloride (CPT-11) for squamous cell carcinomas and malignant melanomas.
- Eccrine Porocarcinoma : DAPI顕微蛍光測光法による細胞核DNA量解析
- 比例ハザードモデルを用いた悪性黒色腫の予後因子の検討
- 悪性黒色腫細胞核DNA量の標準偏差, 変動係数の予後因子的意義について
- 日光角化症に生じ, 免疫組織化学染色にて悪性外毛根鞘腫と考えられた1例
- Survival time analysis of patient ofmalignant melanoma taking account of QOL (quality of life).
- New treatment for operation non-adaptation cancer.8.New proton beam radiation therapy for unresectable hepatoma.
- 前立腺癌の皮膚転移-1症例の報告および筑波大学における内臓癌皮膚転移の統計的観察-
- 巨大腫瘤を呈した熱傷瘢痕有棘細胞癌
- 日光角化症に生じ, 免疫組織化学染色にて悪性外毛根鞘腫と考えられた1例
- Prognostic significance of standard deviation and coefficient of variation of DNA quantity of malignant melanoma cell nucleus.
- 筑波大学皮膚科における悪性黒色腫の統計的観察ならびに予後に関する検討
- Late dermatopathy after proton beam radiation for skin malignant tumor.
- A case of malignant trichilemmoma.
- Eccrine Porocarcinoma.