A case of papillary eccrine adenoma.

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A case of a 37-year-old man with papillary eccrine adenoma is reported. The lesion presented clinically as a slowly growing nodule on the malleolus lateralis of the right foot. Histopathologically, the tumor was composed of multiple dilated tubular structures lined by two or more layers of epithelial cells. In some of the tubules, the inner cell layer formed intraluminal papillary projections.Papillary eccrine adenoma is a rare benign sweat gland neoplasm. There is no consensus on the cellular origin of this tumor. But in this study, we performed immunohistochemical staining study by several monoclonal antibodies against cytokeratin antigens. We reveal that the portion of the two layers of this tumor may defferentiate towards the dermal eccrine duct, whereas, the portion of the papillary projections may defferetiate towards the eccrine secretory portion.
日本皮膚悪性腫瘍学会の論文