Clear cell を伴った Bowen 病の keratin 発現の免疫組織化学的検討

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In this study, six cases of Bowen's disease with clear cells and two cases of solar keratosis (bowenoid type) with clear cells were retrieved and analyzed immunohistochemically by the avidin-biotin-complex method, using a panel of monoclonal anti-keratin antibodies. In Bowen's disease, both tumor cells in conventional lesion and clear cells expressed differentiation specific keratin (CKs 1 and 10). Positive focal staining with antibodies against simple epithelial keratins (CKs 8, 18, and 19) or noncornifying stratified epithelial keratins (CKs 4 and 13) was noted in markedly stypical cells, but not in the other tumor cells including clear cells. With the antibodies 4.1.18 (CK 8) and 170.2.14 (CK 19) which recognized the outer most layer of the outer root sheath, any tumor cells except for above atypical cells failed to react. Furthermore, there was no difference in immunoreactivities between Bowen's disease and solar keratosis. Therefore, it is suggested that the presence of clear cells in Bowen's disease and solar keratosis may not indicate the follicular differentiation in those lesions.
日本皮膚悪性腫瘍学会の論文