Stewart-Treves症候群の2例―治療法を中心に―

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Case 1. A 26-year-old Japanese woman. She underwent mastectamy and axillarylymph node clearance of the left side at age 14. Subcutaneous nodules appeared on the left upper arm one year prior to her first examination which took place on August 1, 1986. The nodules continued enlarging. The left shoulder joint was amputated. One month later, multiple metastases appeared in the lungs and she died six months later.Case 2. A 60-year-old Japanese woman. She received hysterectomy and cobalt irradiation at age 47 because of uterine cancer. Since age 54, lymph edema of the right lower extremity has appeared. A blue fleck appeared on the right thigh 4 monthspreviously than the first examination (November 8, 1993) and later the fleck enlarged. She went into remission after radiation-thermal therapy and intraarterial injections of IL-2. Intraarterial combination immunochemotherapy with IL-2, adriamycin, cyclophosmamide, OK-432 were not so effective for further reccurrences. The tumorous ulcer on the right thigh enlarged to all planes of the right thigh. She died in renal failure amid repeated bacterial infections, loss of fluids and deterioration of the general condition one year and g months later. IL-2 appeared effective for the prevention of distant metastases since she had not shown any distant metastases of the tumor including the lung metastases.