Predictable factors in healing of gastric ulcer, coparative analysis of local morphologic factor of gastric ulcer and suppression of intragastric pH.

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Predictable factors in healing of 48 patients with gastric ulcer by PPI or H<SUB>2</SUB>-RA on 4 and 8 weeks of treatment were investigated. We evaluated the following factors such as patient's profile, local morphologic factors of gastric ulcer and suppression rate of 24hr intragastric pH between healed and unhealed patients using single and multiple variable analysis.<BR> Results obtained from multiple variable analysis, the significant and independent factors of intractable gastric ulcers on the 4th week of treatment were ulcer size in over 20mm and solitary ulcer. On the contrary, those of 8th week of treatment were shortage of holding time of intragastric pH over pH4 (less than 16.7hrs) during treatment, the site of ulcer at lesser curvature of gastric angle and the shape of ulceration which showed mucosal overhanging.<BR> Considering with single and multiple variable analysis, we concluded that, in early phase, local shapes of the ulceration were important predictors in the healing of gastric ulcer, and the after that, the inhibition of intragastric acidity were significant factors in healing process of gastric ulcer.
財団法人日本消化器病学会の論文