ビリルビンカルシウム石における胆汁および胆石中胆汁脂質に関する研究

概要

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Lipids and bile acids in both gallbladder bile and gallstone were analyzed by high-performance liquid chromatography. In comparison with the patients with other types of gallstones, those with calcium bilirubinate stones showed markedly lower concentrations of cholesterol, phospholipids, total bile acid and relatively high lithogenic index in their gallbladder bile. Furthermore, in the patients with calcium bilirubinate stones, free bile acids were detected especially in their gallbladder bile.The weight composition of cholesterol, fatty acids and total bile acids in calcium bilirubinate stones were 10.8%, 6, 3% and 5.3%, respectively. Characteristically, in those stones, 36.5% of total bile acids was free form, while it was not detected in other stones with the exception of one case of a black stone. Our experiment suggested that the conjugated bile acid detected in stones were involved into the stones in process of calcium bilirubinate precipitation and aggregation.