:Comparison of immunoreactive PGI and proteolytic activity

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Determination of serum PGI has become available recently by RIA, but the correlation between immunoreactive PGI and proteolytic activity remains still uncertain. In the present study, immunoreactive PGI was found to correlate well with proteolytic activity at pH 2.0 both in serum and urine.Proteolytic activity at pH 3.5 was also proportional to that at pH 2.0 in urine, but not in serum. This finding was thought to be highly suggestive of difference in the constitution of zymogens active at pH 3.5 between serum and urine. These data showed that both metods of RIA of PGI and proteolytic assay at pH 2.0 were useful to know the functional state of fundic gland of the stomach. Serum level of immunoreactive PGI was 61.9±30.1ng/ml in healthy controls and was high in peptic ulcer, but was low in pernicious anemia and gastrectomized cases. However the high level of immunoreactive PGI found in patients suffering from uremia suggested the importance of renal function from the diagnostic standpoint.
財団法人日本消化器病学会の論文