Effect of trimoprostil on gastric secretion.

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The effects of trimoprostil, an analogue of PGE<SUB>2</SUB>, on gastric secretion was studied inhealthy volunteers in comparison with those of cimetidine . Graded doses of 50, 250, 500, and 750g, were used for trimoprostil and 200 mg for cimetidine. Basal secretion wassignificantly depressed at doses larger than 500 μg of trimoprostil but not by 200 mg ofcimetidine. In AOC-tetragastrin stimulated gastric secretion, 500 μg of trimoprostildepressed acid output, but did not affect pepsin output, which was depressed at 750μg, however. On the other hand, cimetidine inhibited gastrin-stimulated gastric acid andpepsin secretion remarkably. Some difference was also recognized between trimoprostiland cimetidine concerning the mechanism of inhibitory effect. Serum concentration oftrimoprostil was measured at 60 min. after oral administration varied dose-dependentlyand dose-related anti-secretory effects were also found. Serum gastrin and pepsinogen 1were not affected either by trimoprostil or cimetidine. These results indicate thattrimoprostil showed inhibitory effects on gastric secretion at doses larger than 500 μgfor acid, and 750 μg for pepsin.
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