:With special Reference to Effects of Litholytic Agent in Human Bile and to Irrigation of Bile Duct

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The authors examined on dissolution and disintegration of calcium bilirubinate stone in human bile on the basis of the fundamental studies performed at our department.The results obtained were as follows; 1) Slice of calcium bilirubinate stone was readily soluble in the bile with a single addition of tetrasodium salt of ethylenediaminetetraacetic acid (EDTA•4Na). 2) Calcium bilirubinate stone was dissolved in bile with addition of all the three agents of EDTA•4Na, ursodeoxycholate (URSO), and heparin in a more accelerated manner than or in a comparable rate to the case of bile with single addition of EDTA•4Na. 3) The pH of the bile with addition of the triple combination of EDTA•4Na-URSO-heparin was 8.72±0.15, which was slightly more neutral than the case of bile with a single addition of EDTA•4Na (pH9.55±0.05), 4) In the dogs with bile duct dilatation, no abnormality was seen in the results of the hepatic function tests and serum calcium level during the period of irrigation of bile dut for 4 weeks. Nor was there any abnormality in gallbladder and the common bile duct histopathologically. No finding of toxic hepatitis was seen in liver.In conclusion, the solution of the triple combination of EDTA•4Na-URSO-heparin was found to be effective for dissolution and disintegration of calcium bilirubinate stones, and it was estimated that the solution would have extremely little disturbances to human bodies.
財団法人日本消化器病学会の論文

:With special Reference to Effects of Litholytic Agent in Human Bile and to Irrigation of Bile Duct

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