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Pathological and immunohistological study on the 21 cases of non-Hodgkin malignant lymphomas of gastro-intestinal tract were carried out. PAP method using formalin fixed paraffin sections was employed for detection of intracytoplasmic immunoglobulins, lysozyme, CEA and albumin. According to the Rappaport's classification, histologically 8 cases showed nodular type, and 13 cases showed diffuse type. Concerning to the cellular characters, the cases of poorly differentiated lymphocytic type were more numbered than those of large lymphoid type. Monoclonal inttracytoplasmic immunoglobulins were revealed in the tumor cells of 11 cases by PAP method. On the other hand lysozyme was never seen in the tumor cells of the presented cases. Most of the cases which were positive for intracytoplasmic immunoglobulin showed diffuse type. From these results, it was supposed that most of the malignant lymphomas of presented cases were originated from lymphocytes, especially B-lymphocytes.
財団法人日本消化器病学会の論文