:Evaluation on Post-mortem Pancreas

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In an attempt to evaluate histological findings behind pancreatogrphic abnormalities, thirteen postmortem pancreas with cancer were subjected to retrograde pancreatography and histological examination. The materials consist of ten cases of primary adenocarcinoma of the pancreas and three cases of metastatic carcinoma. The results obtained are as follows.1) According to the changes of main pancreatic duc (MPD), pancreatographic findings were classified into four categories: stenosing; obstructing; wide-spread irregular stenosing metastatic carcimoma.2) In the areas where abnormal pancreatographic changes were demonstrated, periductal infiltration of tumor cells was discovered: localized stenosis was caused by compression from either tumor mass or marked fibrosis with scattered tumor cells in it; obstruction was caused by compression from tumor mass; widespread irregular stenosis with tapering was caused by wide-spread conspicuous fibrosis with scattered tumor cells in it. It was difficult to predict the presence or absence of intraductal tumor cell infiltration from the radiographic findings.3) No radiographic changes of MPD were specific for cancer. Abnormal findings of branches such as absence, irregular distribution, displacement and/or shifting, combined with MPD findings, were helpful for the diagnosis of cancer and often for delineating the extension of cancer infiltration. Multiple combinations of these abnormal findings were especially important.However, when the radiographic findings were wide-spread, it was difficult to differentiate pancreatic carcinoma from chronic pancreatitis.4) Pancreatic duct proximal to stenosis was diffusely dilated, and it was impossible to predict the presence of cancer cell infiltration in the area from the pancreatograms.
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:Evaluation on Post-mortem Pancreas

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