STUDY OF EXPERIMENTAL ULCERATIVE COLITIS INDUCED BY CARRAGEENAN IN RABBIT

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We made lesions which resembled those of ulcerative colitis in rabbits and tried to clarify pathogenesis of the disease by studying the lesional tissues at the large intestine histologically together with immunological approach.Rabbits with an average body weight of 2kg were chosen as objects of the study. They were sensitized with 1% physiological saline including λ-degraded-carrangeenan. After 1 week, 0.5% water solution including λ-degraded-carrageenan was given them as drinking water for about 6 weeks.Diarrhea and loss of body weight were seen in the 2nd week of the start of the trial, and bloody stool was observed in 80% of them in the 6th week. Endoscopically, edema was observed in the 2nd week and disseminated erosion and ulcer (ul II) were found in various parts of the large intestine in the 6th week. Histologically, mucosal atrophy, small erosion, cellular infiltration with lymphocytes and plasma cells were seen remarkably in the ulcerative regions and cryptitis was also observed. PHA response was lowered gradually with the time compared with that before the administration of carrageenan in some cases and remained unchanged in other cases. We concluded that immunological mechanisms play and important role in formation of non-specific inflammatory lesion on the mucosa of experimental model, in addition to the direct action of carrageenan.
財団法人日本消化器病学会の論文