Possible Involvement of Glutamatergic Signaling Machineries in Pathophysiology of Rheumatoid Arthritis
スポンサーリンク
概要
- 論文の詳細を見る
The prevailing view is that L-glutamate (Glu) functions as an excitatory amino acid neurotransmitter through a number of molecular machineries required for the neurocrine signaling at synapses in the brain. These include Glu receptors for signal input, Glu transporters for signal termination, and vesicular Glu transporters for signal output through exocytotic release. Although relatively little attention has been paid to the functional expression of these molecules required for glutamatergic signaling in peripheral tissues, recent molecular biological analyses including ours give rise to a novel function for Glu as an extracellular signal mediator in the autocrine and/or paracrine system in several peripheral and non-neuronal tissues, including bone and cartilage. In particular, a drastic increase is demonstrated in the endogenous levels of both Glu and aspartate in the synovial fluid with intimate relevance to increased edema and sensitization to thermal hyperalgesia in experimental arthritis models. However, to date, there is only limited information about the physiological and pathological significance of glutamatergic signaling machineries expressed by articular synovial tissues. In this review, we have outlined the role of Glu in synovial fibroblasts in addition to the possible involvement of glutamatergic signaling machineries in the pathogenesis of joint diseases such as rheumatoid arthritis.
著者
-
Yoneda Yukio
Laboratory Of Molecular Pharmacology Division Of Pharmaceutical Sciences Kanazawa University Graduat
-
Hinoi Eiichi
Laboratory Of Molecular Pharmacology Division Of Pharmaceutical Sciences Kanazawa University Graduat
関連論文
- Inhibition by 2-Methoxy-4-ethylphenol of Ca2+ Influx Through Acquired and Native N-Methyl-D-aspartate–Receptor Channels
- Predominant Promotion by Tacrolimus of Chondrogenic Differentiation to Proliferating Chondrocytes
- Neurogenesis Mediated by γ-Aminobutyric Acid and Glutamate Signaling
- Gradual Downregulation of Protein Expression of the Partner GABABR2 Subunit During Postnatal Brain Development in Mice Defective of GABABR1 Subunit
- Neonatal Phencyclidine Treatment in Mice Induces Behavioral, Histological and Neurochemical Abnormalities in Adulthood
- Functional Proteins Involved in Regulation of Intracellular Ca^ for Drug Development : Preface
- Increased GABA Transport Activity in Rat Calvarial Osteoblasts Cultured under Hyperglycemic Conditions(Pharmacology)
- nrf2 Expressed by Bone(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)
- Release of Endogenous Glutamate by AMPA Receptors Expressed in Cultured Rat Costal Chondrocytes(Pharmacology)
- Glutamate Signaling System in Bone
- Pharmacological Topics of Bone Metabolism : Glutamate as a Signal Mediator in Bone
- Functional Proteins Involved in Regulation of Intracellular Ca^ for Drug Development : Desensitization of N-Methyl-D-aspartate Receptor Channels
- Transcriptional Regulation of Neuronal Genes and Its Effect on Neural Functions : Gene Expression in Response to Static Magnetism in Cultured Rat Hippocampal Neurons
- Neurogenesis Mediated by GABA and Glutamate Signaling
- Ifenprodil severely retards P19 neuronal differentiation via polyamine site of NR2B subunit on NMDA receptors
- A Negative Correlation Between Expression Profiles of Runt-Related Transcription Factor-2 and Cystine/Glutamate Antiporter xCT Subunit in Ovariectomized Mouse Bone
- A Tale of Early Response Genes
- Functional Proteins Involved in Regulation of Intracellular Ca2+ for Drug Development: Desensitization of N-Methyl-D-aspartate Receptor Channels
- Selective Upregulation of Per1 mRNA Expression by ATP Through Activation of P2X7 Purinergic Receptors Expressed in Microglial Cells
- Possible Involvement of Glutamatergic Signaling Machineries in Pathophysiology of Rheumatoid Arthritis
- Inhibition by 2-Methoxy-4-ethylphenol of Ca^ Influx Through Acquired and Native N-Methyl-D-aspartate-Receptor Channels
- Selective Downregulation of N-methyl-D-aspartate Receptor (NMDAR) rather than Non-NMDAR Subunits in Ipsilateral Cerebral Hemispheres in Rats with Middle Cerebral Artery Occlusion
- Gradual Downregulation of Protein Expression of the Partner GABA_BR2 Subunit During Postnatal Brain Development in Mice Defective of GABA_BR1 Subunit
- Possible Involvement of Glutamatergic Signaling Machineries in Pathophysiology of Rheumatoid Arthritis
- Selective Upregulation of Per1 mRNA Expression by ATP Through Activation of P2X7 Purinergic Receptors Expressed in Microglial Cells
- A Negative Correlation Between Expression Profiles of Runt-Related Transcription Factor-2 and Cystine/Glutamate Antiporter xCT Subunit in Ovariectomized Mouse Bone
- Amelioration by the Natural Polyamine Spermine of Cartilage and Bone Destruction in Rats With Collagen-Induced Arthritis
- Delayed Mitochondrial Membrane Potential Disruption by ATP in Cultured Rat Hippocampal Neurons Exposed to N-Methyl-D-Aspartate
- Possible Modulation of Process Extension by N-Methyl-D-aspartate Receptor Expressed in Osteocytic MLO-Y4 Cells
- In Vivo and In Vitro Treatment With Edaravone Promotes Proliferation of Neural Progenitor Cells Generated Following Neuronal Loss in the Mouse Dentate Gyrus
- A Negative Correlation Between Per1 and Sox6 Expression During Chondrogenic Differentiation in Pre-chondrocytic ATDC5 Cells
- Prevention of Bone Loss after Ovariectomy in Mice with Preferential Overexpression of the Transcription Factor Paired Box-5 in Osteoblasts
- In Vivo and In Vitro Treatment With Edaravone Promotes Proliferation of Neural Progenitor Cells Generated Following Neuronal Loss in the Mouse Dentate Gyrus
- A Negative Correlation Between Per1 and Sox6 Expression During Chondrogenic Differentiation in Pre-chondrocytic ATDC5 Cells