Amelioration by the Natural Polyamine Spermine of Cartilage and Bone Destruction in Rats With Collagen-Induced Arthritis
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概要
- 論文の詳細を見る
We investigated pharmacological properties of naturally occurring polyamines on cartilage and bone destruction seen in joints of rats with collagen-induced arthritis (CIA). Daily supplementation of spermine (SPM), but not spermidine, significantly inhibited increases in the hind paw volume and arthritis score in CIA rats, in addition to the increased mRNA expression of receptor activator of nuclear factor-<I>κ</I>B ligand in both cartilage and synovial tissues. Histological analysis clearly revealed a drastic prevention by SPM of the cartilage and bone destruction in synovial joints of CIA rats. Particular natural polyamines would be beneficial for the prophylaxis of synovial joint destruction in rheumatoid arthritis.
- 公益社団法人 日本薬理学会の論文
- 2012-05-20
著者
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Yoneda Yukio
Lab. Of Molecular Pharmacology Div. Of Pharmaceutical Sciences Kanazawa Univ. Graduate School Of Nat
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Yoneda Yukio
Laboratory Of Molecular Pharmacology Division Of Pharmaceutical Sciences Kanazawa University Graduat
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Hinoi Eiichi
Lab. Of Molecular Pharmacology Div. Of Pharmaceutical Sciences Kanazawa Univ. Graduate School Of Nat
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Hinoi Eiichi
Laboratory Of Molecular Pharmacology Division Of Pharmaceutical Sciences Kanazawa University Graduat
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Yamamoto Tomomi
Laboratory Of Molecular Pharmacology Division Of Pharmaceutical Sciences Kanazawa University Graduat
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Ogawa Shinya
Laboratory Of Biological Protection Department Of Biological Responses Institute For Virus Research
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Ogawa Shinya
Laboratory Of Molecular Pharmacology Division Of Pharmaceutical Sciences Kanazawa University Graduate School Of Natural Science And Technology
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Ishiura Ryo
Laboratory Of Molecular Pharmacology Division Of Pharmaceutical Sciences Kanazawa University Graduate School Of Natural Science And Technology
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IEZAKI Takashi
Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School of Natural Science and Technology
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Iezaki Takashi
Laboratory Of Molecular Pharmacology Division Of Pharmaceutical Sciences Kanazawa University Graduate School Of Natural Science And Technology
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Yamamoto Tomomi
Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School of Natural Science and Technology
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