Mutagenicities and Endocrine-disrupting Activities of 1-Hydroxy-2-nitropyrene and 1-Hydroxy-5-nitropyrene
スポンサーリンク
概要
- 論文の詳細を見る
The mutagenicities and endocrine-disrupting activities of two isomers of mononitrated 1-hydroxypyrene [1-hydroxy-x-nitropyrenes (1-OH-x-NPs); x = 2 and 5], which are not only photoreaction products of 1-nitropyrene (1-NP) but also constituent of ambient airborne particles, were evaluated for the first time using the Ames plate incorporation assay and the yeast two-hybrid assay, respectively. The mutagenicity of 1-OH-5-NP was weakly positive in the absence of rat liver S9, but was enhanced up to 3-fold with the metabolic activation by S9. On the contrary, 1-OH-2-NPdid not exhibit significant mutagenicity in the presence or absence of S9. 1-OH-5-NP showed weak estrogenic activity, but 1-OH-2-NP did not show any estrogenic activity. The concentration of 1-OH-5-NP that gave 10% of activity of 1.0 × 10-6M 17ß- estradiol (E2) was 5.4 × 10-7M. 1-OH-5-NP exhibited stronger antiestrogenic and antiandrogenic activities than 1-OH-2-NP. 1-OH-5-NP at a concentration of 1.0 × 10-6M inhibited 71 and 90%of ß-galactosidase activity induced by 1.0 × 10-9Mof E2 and 1.0 × 10-8M of 5a-dihydrotestosterone (DHT), respectively. On the other hand, 1.0 × 10-6M of 1-OH-2-NP inhibited 16 and 43% of ß-galactosidase activity induced by 1.0 × 10-9M of E2 and 1.0 × 10-8M of DHT, respectively. These findings point out the need for determining the environmental sources and distribution of 1-OH-2-NP and 1-OH-5-NP as well as the other hydroxynitropyrene isomers. © 2011 The Pharmaceutical Society of Japan.
- Pharmaceutical Society of Japan = 日本薬学会の論文
著者
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近藤 隆
富山大学 生命科学先端研究センター
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近藤 隆
富山大学 大学院医学薬学研究部薬品製造学研究室
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HAYAKAWA Kazuichi
Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University
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Kondo T
Osaka Univ. Osaka Jpn
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Kondo Tetsuya
Storage Technologies Research Center Victor Company Of Japan Limited
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Kondo Takahiro
Institute Of Applied Physics University Of Tsukuba
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近藤 隆
富山医薬大・医
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近藤 隆
神戸大学医学部放射線基礎医学教室
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Kondo T
National Lab. High Energy Physics Tsukuba
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Masamune Y
Department Of Microbiology Faculty Of Pharmaceutical Sciences Kanazawa University
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Hayakawa Kazuichi
Institute Of Medical Pharmaceutical And Health Sciences Kanazawa University
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Miyata Yoshiaki
Graduate School Of Natural Science And Technology Kanazawa University
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Tang Ning
Institute Of Medical Pharmaceutical And Health Sciences Kanazawa University
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Kameda Takayuki
Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University
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Yoshita Morio
Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University
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Tachikawa Chihiro
Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University
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Toriba Akira
Institute Of Medical Pharmaceutical And Health Sciences Kanazawa University
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Akiyama Ayuko
Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University
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Kameda Takayuki
Department Of Radiological Sciences Graduate School Of Medicine And Pharmaceutical Sciences Universi
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Kondo Takashi
Department Of Radiological Sciences Graduate School Of Medicine And Pharmaceutical Sciences Universi
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Kondo Takashi
Department Of Radiological Sciences Faculty Of Medicine Toyama Medical And Pharmaceutical University
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