体表循環モニターシステムの開発と応用 : 第1報 基礎的研究
スポンサーリンク
概要
- 論文の詳細を見る
The thermal diffusion method is based on a linear relationship between thermal conductivity of tissue and the tissue blood flow. Therefore, thermal diffusion is very sensitive to changes in tissue blood flow. However, it has been impossible to assess tissue blood flow quantitatively by this method. For the quantitative dynamic assessment of body surface circulation, a thermal diffusion flow probe incorporating a Peltier stack was used. In order to modify the apparatus using this probe for measuring body surface circulation continuously, fundamental studies about the measurement of human skin blood flow were carried out in the finger using the thermal diffusion method. The results obtained were as follow.1) The voltage difference of the thermocouples (V) of a probe placed on plates of various materials similar in the thermal conductivity to human skin was measured. A highly positive correlation between the thermal conductivity of the material and the reciprocal number of the voltage difference of the thermocouples (1/V) (r=0.973, p<0.001) could be observed. The use of this probe enabled us to assess the thermal conductivity of materials and tissues quantitatively.2) V gradually increased in parallel with the finger ischemia induced by inflation of a touniquet, suggesting that V varied with the change of finger blood flow and that its baseline was steady.3) A highly significant positive correlation was obtained between finger blood flow measured by the inhaled hydrogen clearance method (Hydrogeni FBF) and 1/V (r=0.949, p<0.001). V with no flow (V0) and constant Φ was estimated, and a calibrating line based on the following equation was determined.F=Φ(1/V-1/V0)Finger blood flow measured by the thermal diffusion method (Thermal FBF) was obtained. A highly significant positive correlation was obtained between Hydrogeni FBF and Thermal FBF (r=0.949, p<0.001).4) A highly significant positive correlation was obtained between finger blood flow measured by an electrochemically generated hydrogen clearance method (Hydrogene FBF) and 1/V (r=0.953, p<0.001). Calibration by this method was carried out taking account of the apparent flow by diffusion of hydrogen gas to the surrounding area (Diffusion Flow). A highly significant positive correlation was obtained between Hydrogene FBF subtracted Diffusion Flow and Thermal FBF (r=0.953, p<0.001).5) Thermal FBF calibrated by the electrochemically generated hydrogen clearance method almost agreed with that determined by the inhaled hydrogen clearance method in terms of the absolute value of the finger blood flow.Using the thermal diffusion method calibrated previously by the hydrogen clearance method in normal human subjects, the absolute value of skin blood flow can be measured continuously and noninvasively in humans. It was concluded that the apparatus for measuring skin blood flow continuously by the thermal diffusion method could be utilized as a monitor of the body surface circulation and was thus useful for diagnosis and research in various medical fields.
- 日本衛生学会の論文
著者
関連論文
- 熱クリアランス曲線を用いた組織血流量の測定
- チェンソー作業者の症状発現と作業,生活,身体要因との関連についての多変量解析
- チェンソー作業者の自覚症状に関する多変量解析
- 14. 振動障害 : 新しい診断手法(最近の進歩シリーズ,特別報告,第61回日本産業衛生学会・第44回日本産業医協議会)
- 全身振動刺激に対するラット脳内DOPACおよびVIP様免疫活性の応答
- 体表循環モニターシステムの開発と応用 : 第1報 基礎的研究
- 体表循環モニターシステムの開発と応用 : 第2報 診断的応用
- 振動工具使用者のSustained Handgripに対する末梢循環反応
- 女子における嗜好品及び食品嗜好と不定愁訴との関連--嗜好の因子構造による解析
- 健康状態に関わるライフ・スタイルの構造分析-1-健康実践,社会的ネットワ-クと健康状態との相互関連について
- Relationship between Serum Uric Acid and Serum Lipid Peroxides