HISTOCHEMICAL ANALYSIS OF LOCAL IMMUNE SYSTEM IN THE MIDDLE EAR
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概要
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To clarify the manifestations of a local immune system of the middle ear, 50 guinea pigs were examined histopathologically after various immunologic stimmulations were given. The animals were classified into 4 groups by the methods of immunizations: 1) non-sensitized group, 2) intrabullar injection group, 3) intradermal injection group, and 4) intradermal and intrabullar injection group. Horseradish peroxidase (HRP) was used as an antigen and the animals of each group were rechallenged by intraperitoneal, intranasal, or intrabullar HRP injection. The local immunity of the middle ear was acquired only by the general immunization, and was enhanced by the additional local challenge. The local immune system consisted of resident macrophage containing antigen within its cytoplasm, lymphocytes forming lymph follicle-like structure, and the plasma cell producing specific antibody against challenged antigen. Immunoelectronmicroscopical observation also demonstrated the differentiation from the lymphocytes to the mature plasma cells producing specific antibody in the submucosal connective tissue. These immunocytes seemed to be under regulation of the newly formed capillary net-works with high columner endothel and chemical mediators such as macrophage chemotactic factor as well as macrophage migration inhibitory factor in the middle ear effusion. To produce middle ear effusion, intratympanic inoculation was the only effective stimulation. Intranasal injection with nebulized vapor could not bring the antigen into the middle ear, and circulating immune complex could not be a pathogen of otitis media.
- 社団法人 日本耳鼻咽喉科学会の論文
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