A Case of a Giant Glucagonoma with Parathyroid Hormone-related Peptide Secretion Showing an Inconsistent Postsurgical Endocrine Status
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概要
- 論文の詳細を見る
A 53-year-old woman was admitted because of a giant pancreatic tumor. Hypercalcemia and a high serum parathyroid hormone-related peptide (PTHrP) level were observed. A hypoglycemic attack occurred during pancreatectomy, and the surgical specimen revealed a PTHrP-secreting glucagonoma. Liver metastases developed 1 and 5.5 years later, and bone metastases appeared 6 years after surgery. Her serum PTHrP concentrations remained normal after surgery, despite re-elevation of the serum glucagon concentration after recurrence. The clinical course of this case illustrates the process of development of neuroendocrine tumors secreting two or more hormones.
著者
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Ichinose Masao
The Second Department Of Internal Medicine Wakayama Medical University
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Yasuoka Hironao
Department Of Pathology Wakayama Medical University
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Iso-o Naoyuki
Department Of Metabolic Disease University Of Tokyo Graduate School Of Medicine
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Nakamura Yasushi
Department Of Agricultural Chemistry Faculty Of Agriculture Niigata University
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Oka Masashi
The Second Department of Internal Medicine, Wakayama Medical University, Japan
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Yamaue Hiroki
The Second Department of Surgery, Wakayama Medical University, Japan
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Tamai Hideyuki
The Second Department of Internal Medicine, Wakayama Medical University
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Ichinose Masao
The Second Department of Internal Medicine, Wakayama Medical University, Japan
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Kawai Manabu
The Second Department of Surgery, Wakayama Medical University, Japan
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Shirai Kiyokazu
The Second Department of Internal Medicine, Wakayama Medical University, Japan
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Inoue Izumi
The Second Department of Internal Medicine, Wakayama Medical University, Japan
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Kato Jun
The Second Department of Internal Medicine, Wakayama Medical University, Japan
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Maeda Hiroki
The Second Department of Internal Medicine, Wakayama Medical University, Japan
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Moribata Kosaku
The Second Department of Internal Medicine, Wakayama Medical University, Japan
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Shingaki Naoki
The Second Department of Internal Medicine, Wakayama Medical University, Japan
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Ueda Kazuki
The Second Department of Internal Medicine, Wakayama Medical University, Japan
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Deguchi Hisanobu
The Second Department of Internal Medicine, Wakayama Medical University, Japan
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Maekita Takao
The Second Department of Internal Medicine, Wakayama Medical University, Japan
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Iguchi Mikitaka
The Second Department of Internal Medicine, Wakayama Medical University, Japan
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Yanaoka Kimihiko
The Second Department of Internal Medicine, Wakayama Medical University, Japan
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Yasuoka Hironao
Department of Clinical Laboratory Medicine, Wakayama Medical University, Japan
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