Pancreatic Stone Protein/Regenerating Protein Family in Pancreatic and Gastrointestinal Diseases
スポンサーリンク
概要
- 論文の詳細を見る
Pancreatic stone protein (PSP; reported in 1979), pancreatitis-associated protein (PAP; 1984) and regenerating protein (Reg I; 1988) were discovered independently in the fields of the exocrine (pancreatitis) and endocrine (diabetes) pancreas. Subsequent analysis revealed that PSP and Reg I are identical and PAP belongs to the same protein family. PSP/Reg I and PAP share a selective and specific trypsin cleavage site and result in insoluble fibrils (PTP, PATP). Search for a functional role of PSP had led to the idea that it might serve as an inhibitor in pancreatic stone formation and PSP was renamed lithostathine. Inhibitory effects of lithostathine in stone formation have been questioned. Evidence so far obtained can support a lithogenic role rather than a lithostatic role of PSP. PAP and its isoforms have been investigated mainly regarding responses to inflammation and stress. Reg I and its isoforms have been examined on regeneration, growth and mitogenesis in gastrointestinal neoplastic diseases as well as diabetes. Evidence obtained can be applied in the prediction of prognosis and therapy for inflammatory and neoplastic diseases.
著者
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HAYAKAWA Tetsuo
Meijo Hospital
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Ko Shigeru
Department Of Gastroenterology Nagoya University Graduate School Of Medicine
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Ishiguro Hiroshi
Department Of Adaptive Machine Systems Graduate School Of Engineering Osaka University
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Kitagawa Motoji
Department Of Epidemiology And Environmental Health Juntendo University School Of Medicine
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Ko Shigeru
Department of Gastroenterology, Nagoya University Graduate School of Medicine, Japan
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Jin Chun
The First Clinical College of Norman Bethune Medical Division, Jilin University, China
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Kitagawa Motoji
Department of Nutritional Science, Nagoya University of Arts and Science, Japan
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