Lactoferrin in Gastrointestinal Disease
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概要
- 論文の詳細を見る
Lactoferrin, a major whey protein, is a red iron-binding protein present mainly in external secretions such as breast milk and in polymorphonuclear neutrophils. The presence of lactoferrin in body fluids is proportional to the flux of neutrophils and its assessment can provide a reliable biomarker for inflammation. In gastrointestinal diseases increased fecal lactoferrin is a sensitive and specific surrogate marker for inflammatory bowel diseases in patients with chronic diarrhea and pain, and ascites lactoferrin can also provide a promising and reliable biomarker for bacterial peritonitis. Lactoferrin in pancreatic juice and stone could provide pathophysiological information of protein plug and stone formation in the pancreatic duct. Serum anti-lactoferrin autoantibody might contribute to the clarification of the pathogenetic mechanisms of autoimmune pancreatitis and liver diseases, although its diagnostic and prognostic value appears to be limited. Further studies will be necessary to elucidate the exact details.
- 社団法人 日本内科学会の論文
著者
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HAYAKAWA Tetsuo
Meijo Hospital
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B. H.
Department Of Gastroenterology Nagoya University Graduate School Of Medicine
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Ishiguro Hiroshi
Department Of Adaptive Machine Systems Graduate School Of Engineering Osaka University
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Kitagawa Motoji
Department Of Epidemiology And Environmental Health Juntendo University School Of Medicine
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Jin Chun
The Second Clinical College of Norman Bethune Medical Division, Jilin University
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Kitagawa Motoji
Department of Nutritional Science, Nagoya University of Arts and Science
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