Synthesis of New α-Glucosidase Inhibitors Based on Oleanolic Acid Incorporating Cinnamic Amides

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概要

• 論文の詳細を見る

• A series of α-glucosidase inhibitors with the oleanolic acid core and different cinnamic amide ligands were designed and synthesized. Their preliminary structure–activity relationships were analyzed. In general, the compounds with 3,28-disubstituted oleanolic acid exhibited stronger activity than those 28-monosubstituted analogues, and variation of cinnamic amide substitution significantly affected α-glucosidase inhibition activities. Most of the compounds showed potent inhibitory activity against α-glucosidase with much greater efficacy than a typical α-glucosidase inhibitor, acarbose.

• 公益社団法人　日本薬学会の論文

著者

• Luo Jian-Guang

  Department of Natural Medicinal Chemistry, China Pharmaceutical University

• Kong Ling-Yi

  Department of Natural Medicinal Chemistry, China Pharmaceutical University

• Luo Jian-guang

  Dep. Of Natural Medicinal Chemistry China Pharmaceutical Univ.

• Wang Xiao-Bing

  Department of Natural Medicinal Chemistry, China Pharmaceutical University

• YIN Hong

  Department of Cancer Research, Research Institute for Radiation Biology and Medicine, Hiroshima Univ

• Luo Jian-guang

  Department Of Natural Medicinal Chemistry China Pharmaceutical University

• Kong Ling-yi

  Department Of Natural Medicinal Chemistry China Pharmaceutical University

• Nie Wei

  Department of Natural Medicinal Chemistry, China Pharmaceutical University

• Sun Hong-Bin

  Department of Medicinal Chemistry, China Pharmaceutical University

• Yao He-Quan

  Department of Medicinal Chemistry, China Pharmaceutical University

• Yin Hong

  Department of Natural Medicinal Chemistry, China Pharmaceutical University

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