Tumorigenesis in Infant C3H/HeN Mice Exposed to Tritiated Water (HTO)
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概要
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The purpose of this study was to determine the carcinogenicity and retention of tritiated water (HTO) in mice. A two-part study was undertaken. In an HTO-incorporation study, both sexes of 12-day old C3H/HeN mice were i.p. injected with 3.70 MBq/pup of HTO and sacrificed 3 hr and 1, 3, 7, 14 days after HTO administration; in a carcinogenicity study, pups were given a single i.p. injection of HTO at doses of 0, 0.23, 0.92 and 3.70 MBq/mouse, and then observed for 14 months. The survival rates of both sexes slightly decreased upon increasing the HTO administered doses. The results indicated that the administration of HTO to infants led to a significant increase of liver tumors in male mice, but not in females. In female mice, ovarian tumors were observed for the high-dose group of injected HTO.
- 日本放射線影響学会の論文
著者
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FUJIMOTO Nariaki
Department of Cancer Research, Hiroshima University
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ITO Akihiro
Department of Cancer Research, Hiroshima University
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Ito A
Department Of Cancer Research Research Institute For Radiation Biology And Medicine Hiroshima Univer
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Ito Akihiro
広島大学原爆放射能医学研究所
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YIN Hong
Department of Cancer Research, Research Institute for Radiation Biology and Medicine, Hiroshima Univ
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Fujimoto N
Hiroshima Univ. Hiroshima Jpn
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Fujimoto Nariaki
広島大学原爆放射能医学研究所
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Fujimoto Nariaki
Department Of Cancer Research Rirbm Hiroshima University
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Fujimoto Nariaki
Department Of Cancer Research Institute Of Radiation Biology And Medicine Hiroshima University
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Yin Hong
蘭州獣医研究所
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BHATTACHARJEE DILIP
Department of Cancer Research, Research Institute for Radiation Biology and Medicine, Hiroshima Univ
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ROY GOUTUM
Department of Cancer Research, Research Institute for Radiation Biology and Medicine, Hiroshima Univ
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NAKATANI TAMAKI
Department of Cancer Research, Research Institute for Radiation Biology and Medicine, Hiroshima Univ
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Roy G
Hiroshima Univ. Hiroshima Jpn
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Roy Goutum
Department Of Cancer Research Research Institute For Radiation Biology And Medicine Hiroshima Univer
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Bhattacharjee Dilip
Department Of Cancer Research Research Institute For Radiation Biology And Medicine Hiroshima Univer
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Ito A
Department Of Cancer Research Research Institute For Radiation Biology And Medicine (rirbm) Hiroshim
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Yin Hong
Laboratory Of Integrative Brain Sciences Department Of Biology Faculty Of Education And Integrated A
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Yin Hong
広島大学原爆放射能医学研究所
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Ito Akihiro
Department Of Cancer Research Institute Of Radiation Biology And Medicine Hiroshima University
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Nakatani Tamaki
Department Of Cancer Research Research Institute For Radiation Biology And Medicine Hiroshima Univer
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