Twelve Novel and Diverse 16-Norphragmalin-Type Limonoids from Chukrasia tabularis var. velutina
スポンサーリンク
概要
- 論文の詳細を見る
A series of novel and structurally related C-15-acyl 16-norphragmalin-type limonoids, chuktabrins C—J (1—8) and chuktabularins U-X (9—12), were isolated from the stem bark of Chukrasia tabularis var. velutina. Their structures were established on the basis of detailed spectroscopic analysis, and the absolute configuration of compound 1 was determined by a single-crystal X-ray study using a mirror CuKα radiation. Compounds 7 and 8 were unprecedent C-15-acyl 16-norphragmalins with ketonic alkyl appendage at C-15, and compounds 4 and 8 were first examples of limonoid with a characteristic carbonate moiety esterified at OH-9/OH-8 or OH-1/OH-8 respectively. A biosynthetic pathway of these limonoids was reasonably presumed based on the novel and diverse structures isolated, which provides a new insight into the plausible biosynthesis of C-15-acyl 16-norphragmalin-type limonoids. The anti-inflammatory activity of major isolates were evaluated for inhibitory activity against lipopolysaccharide (LPS) induced nitric oxide (NO) production in macrophage (RAW264.7) cell line, with IC50 value ranging from 2.40 to 16.90 μM.
著者
-
Luo Jian-Guang
Department of Natural Medicinal Chemistry, China Pharmaceutical University
-
Wang Jun-Song
Department of Natural Medicinal Chemistry, China Pharmaceutical University
-
Luo Jun
Department of Natural Medicinal Chemistry, China Pharmaceutical University
-
Wang Xiao-Bing
Department of Natural Medicinal Chemistry, China Pharmaceutical University
-
Luo Jian-guang
Department Of Natural Medicinal Chemistry China Pharmaceutical University
-
Luo Jun
Department Of Electronic Engineering Shanghai Jiaotong University
-
Kong Ling-yi
Department Of Natural Medicinal Chemistry China Pharmaceutical University
-
Li Yi
Testing & Analysis Center, Nanjing Normal University
-
Lu Juan
Department of Natural Medicinal Chemistry, China Pharmaceutical University
関連論文
- Triterpenoid Saponins from Gypsophila altissima L.
- Novel Nortriterpenoids from Aphanamixis grandifolia
- Phragmalin-Type Limonoid Orthoesters from Chukrasia tabularis var. velutina
- Inertial Sensor and Its Application to Space Fundamental Physics
- Test of the Equivalence Principle with Optical Readout in Space
- Progress in the Development of Inertial Sensor for ASTROD I
- Null Test of Newtonian Inverse-Square-Law at Short Range : Current Status and Developments(VIII Asia-Pacific International Conference on Gravitation and Astrophysics (ICGA8))
- Measurements of Casimir Force and its Thermal Effects in Space
- Proposal for Testing Non-Newtonian Gravitational Force in Space
- Effects of Yttrium and Erbium Additions on Glass-Forming Ability and Mechanical Properties of Bulk Glassy Zr-Al-Ni-Cu Alloys
- Analysis of the Energy-QoS Tradeoff for Contention-Based Wireless Sensor Networks with Synchronous Wakeup Patterns
- Three New Triterpenoid Saponins from Dianthus superbus
- Four New Sesquiterpenoids from the Fruits of Alpinia oxyphylla
- Two New Monodesmosidic Triterpene Saponins from Gypsophila oldhamiana
- Biotransformation of Ferulic Acid into Two New Dihydrotrimers by Momordica charantia Peroxidase
- Three New Pentasaccharide Resin Glycosides from the Roots of Sweet Potato (Ipomoea batatas)
- Synthesis of New α-Glucosidase Inhibitors Based on Oleanolic Acid Incorporating Cinnamic Amides
- Three New Phenolic Glucosides from the Roots of Rheum palmatum
- Twelve Novel and Diverse 16-Norphragmalin-Type Limonoids from Chukrasia tabularis var. velutina
- Different Pathways for Ca2+ Influx and Intracellular Release of Ca2+ Mediated by Muscarinic Receptors in Ileal Longitudinal Smooth Muscle.
- Serum total oxidant/antioxidant status and trace element levels in breast cancer patients