Role of Pituitary Gland in Melanin Synthesis in Tadpole Skin

概要

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Injection of a homogenate of the pituitary gland of bull frog tadpoles remarkably increased the tyrosinase activity in the skin of hypophysectomized toad tadpoles. The enhancement of the enzyme activity was blocked by the simultaneous treatment with actinomycin D (Act. D), indicating that the increase in activity by the homogenate is closely related to RNA synthesis.<BR>Activation of the enzyme of the skin by the pituitary homogenate injection was greater in hypophysectomized tadpoles than in normal. When the hypophysectomized tadpoles were subjected temporarily to the influence of the pituitary in advance of the treatment with the pituitary homogenate, the activation of the enzyme the homogenate injection was reduced to a level observed in normal tadpoles, suggesting that some regulatory mechanisms concerning tyrosinase activity develop in skin during the embryonic period under the influence of pituitary hormones.
社団法人日本内分泌学会の論文