Alteration by Neonatal Hypothyroidism of the Critical Period for the Induction of Persistent Estrus in the Rat
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概要
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The effects of hypothyroidism for a short period of postnatal life on the induction of persistent estrus by androgen were investigated in female rats of 10 and 13 days of age. Hypothyroidal new born rats produced by feeding propyl thiouracil (PTU) to the mother rats, were more succeptible to the persistent-estrus inductive influence of androgen than normal and thyroxine-therapied hypothyroidal rats of the same age.It is concluded that the period during which androgen exerts a persistent-estrus inductive influence was prolonged in hypothyroidal rats, possibly as the result of the retardation of development of the hypothalamic region, the site affected primarily by androgen.
- 社団法人 日本内分泌学会の論文
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