Estrous Cycle of Mouse with Subcutaneous Pellet Implant of Ergocornine and 2-Br-α-Ergokryptin

概要

論文の詳細を見る
The estrous cycle was examined in the mouse implanted the pellet of ergocornine or 2-Br-α-ergokryptin (CB-154), and subsequently grafted one isologous anterior pituitary. Ergocornine or CB-154 was thoroughly mixed with cholesterol at the ratio of 1:4, pelleted in the size of 5mm diameter and 2mm thickness and implanted subcutaneously to each experimental mouse. The control mice received the same size of pellets of cholesterol only. Approximately 4 weeks after pellet implantation, all mice were given one isologous pituitary graft each under kidney capsule. The vaginal smearings were made every morning throughout the experiment beginning on the day of pellet implantation.<BR>In the control mice, the estrous cycles were not altered by cholesterol pellet implantation and the diestrous periods were prolonged by the subsequent pituitary grafting. On the other hand, the diestrous period was shortened and its elongation by pituitary grafting was markedly inhibited in the mice bearing pellets of ergocornine or CB-154. These results are attributed to the suppressing actions of these ergot alkaloids on pituitary prolactin secretion, and indicate that these drugs inhibit prolactin secretions not only from the <I>in situ</I> pituitary but also from the grafted pituitary.
社団法人日本内分泌学会の論文