Inhibitory Effect of Estrogen on Mammary Growth and Its Counteraction by Pituitary Isograft in Mice
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概要
- 論文の詳細を見る
Mammary growth was markedly inhibited in mice by a single subcutaneous injection of 100μg hexestrol dicaprylate despite the fact that the pituitary prolactin levels were significantly higher in these mice than in the intact controls. The degeneration of mammary gland was completely counteracted by the simultaneous isologous pituitary grafting, indicating that the additional supply of prolactin from the grafts overcame the inhibitory action of estrogen on mammary growth. These results have demonstrated the existence of antagonistic effects between prolactin and estrogen on mammary growth in mice at some dose levels of estrogen.
- 社団法人 日本内分泌学会の論文
著者
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NAGASAWA HIROSHI
Pharmacology Division, National Cancer Center Research Institute
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YANAI REIKO
Pharmacology Division, National Cancer Center Research Institute
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YANAI REIKO
Pharmacology Division National Cancer Center Research Institute
関連論文
- FURTHER STUDY ON THE RELATION BETWEEN AREA AND DESOXYRIBONUCLEIC ACID CONTENT OF THE MAMMARY GLAND IN MICE
- Changes in Serum Prolactin Levels Shortly before and after Parturition in Rats
- Inhibitory Effect of Estrogen on Mammary Growth and Its Counteraction by Pituitary Isograft in Mice
- Prolactin Binding in Pregnancy-Dependent Mammary Tumors in GR/A Mice
- Estrous Cycle of Mouse with Subcutaneous Pellet Implant of Ergocornine and 2-Br-α-Ergokryptin
- Increased Mammary Gland Response to Pituitary Mammotropic Hormones by Estrogen in Rats
- Quantitative Participation of Placental Mammotropic Hormones in Mammary Development During Pregnancy of Mice
- Physiological Significance of Short-Loop Feedback of Prolactin in Female Mice
- Some Immunological Properties of Rabbit Antiserum to Mouse Prolactin
- AGE-, STRAIN-, AND SEX-DIFFERENCES IN THE ANTERIOR PITUITARY GROWTH HORMONE CONTENT OF MICE
- Long-term effects of perinatal exposure to 5.ALPHA.-dihydrotestosterone on normal and neoplastic mammary development in mice.
- Synthesis and Release of Prolactin in vitro from the Anterior Pituitary of Mouse During Estrous Cycle
- DISC ELECTROPHORETIC ANALYSIS OF GROWTH HORMONE AND PROLACTIN IN THE ANTERIOR PITUITARY OF MOUSE