AGE-, STRAIN-, AND SEX-DIFFERENCES IN THE ANTERIOR PITUITARY GROWTH HORMONE CONTENT OF MICE
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概要
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The growth, the anterior pituitary weight, and the anterior pituitary growth hormone (GH) content of C3H/He and C57BL/6 strains of mice were investigated during 12-120 days of age in the male and 30-90 days of age in the female. The pituitary GH content was measured by disc electrophoresis. The pattern of growth and the increasing rate of body weight were similar in either strain, whereas the body weight of C3H/He was always greater than that of C57BL/6 in both sexes. The whole pituitary weight increased with age until 40-60 days and became plateau thereafter in the male of both strains and the C57BL/6 female. On the other hand, the pituitary weight of the C3H/He female continued to increase until the 90th day. Although the pituitary weights were greater in C3H/He than in C57BL/6 until the 60th and 90th days of age in both sexes the pattern of its change was little different according to the strains. The variation of the relative pituitary weight per 10g body was not so remarkable with age in both strains and sexes. In both strains, the total GH content and the relative GH content per 10g body changed in a similar pattern with age, which increased until 50-60 days of age and became plateau or inclined to decrease a little after that in the male, while they continued to increase until the 90th day in the female. The total GH content in C3H/He was significantly higher than that in C57BL/6 in either sex. The relative GH content per 10g body showed no difference between strains in the male, but it was higher in C3H/He than in C57BL/6 in the female. In C3H/He, the female excelled the male not only in the total GH content but also in the GH content per 10g body on the 60th and 90th days. On the other hand, Iittie sex-differences were observed in these areas in C57BL/6. The GH content per mg pituitary showed no noticeable variations with age, strain and sex. The significance of these findings was discussed.
- 社団法人 日本内分泌学会の論文
著者
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NAGASAWA HIROSHI
Pharmacology Division, National Cancer Center Research Institute
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YANAI REIKO
Pharmacology Division, National Cancer Center Research Institute
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NAGASAWA HIROSHI
Pharmacology Division, National. Cancer Center Research Institute
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