Biological Activities of Tyrosine-Containing Somatostatin Analogs on Inhibition of Secretion of Thyrotropin and Growth Hormone

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概要

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• The following five tyrosine-containing analogs of somatostatin (GIF) were synthesized by the solid-phase method: Tyr-GIF;[Tyr<SUP>6</SUP>]-GIF;[Tyr<SUP>7</SUP>]-GIF;[Tyr<SUP>8</SUP>]-GIF;[Tyr<SUP>11</SUP>]-GIF.These analogs except [Tyr<SUP>8</SUP>]-GIF were demonstrated to possess almost the same potency to inhibit thyrotropin release stimulated by thyrotropin-releasing hormone as that of synthesized GIF <I>in vivo</I>.[Tyr<SUP>8</SUP>]-GIF had potencies less than 0.5% of GIF. They also had the activity to inhibit Nembutal-induced growth hormone rise. The structure-activity relationship and availability of these analogs for radioimmunoassay were discussed.

• 社団法人 日本内分泌学会の論文

著者

• SAWANO SHINJI

  Department of Endocrinology and Metabolism, Toranomon Hospital

• OHASHI SHINICHI

  Research Institute for Polymers and Textiles

• KOKUBU TOMOKUNI

  Research Institute for Polymers and Textiles

• GONDO MASAAKI

  Chemical Research Laboratory, Teikoku-Hormone-MFG Co. Ltd.

• SAKAKIBARA KYOICHI

  Chemical Research Laboratory, Teikoku-Hormone-MFG Co. Ltd.

• Sawano Shinji

  Department Of Endocrinology And Metabolism Toranomon Hospital

関連論文

• The Results of Transsphenoidal Surgery for 44 Consecutive Acromegalic Patients
• Biological Activities of Tyrosine-Containing Somatostatin Analogs on Inhibition of Secretion of Thyrotropin and Growth Hormone
• Variety of GH and TSH Responses to Somatostatin in Perifused Rat Pituitaries in Vitro
• Effect of Theophylline on Insulin, Glucagon and Somatostation Secretion from the Isolated Rat Pancreatico-Duodenal Preparation
• Extraction and Partial Purification of Prolactin-Release Stimulating Factor in Bovine Hypothalami
• Effect of a Bovine Hypothalamic Factor on the Release and Biosythesis of Growth Hormone
• In vitro and and in vivo Studies on the Regulation of Somatostatin Release by Adrenergic Mechanism in Normal and Diabetic Rats
• Reproducibility of Plasma Growth Hormone and Insulin Responses after Double Infusion of Arginine Solution
• The Effect of Glucose and Tolbutamide on Immunoreactive Somatostatin Release from Perifused Pancreatic Islets of Normal and Streptozotocin Diabetic Rats
• Effect of Synthetic Growth Hormone-Release Inhibiting Factor on the Secretion of Growth Hormone and Prolactin in Rats
• Simultaneous Determinations of Plasma ACTH and GH Levels after an Oral Metyrapone

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