Effects of biogenic amines on the formation of adenosine 3',5'-monophosphate in human thyroid slices.
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概要
- 論文の詳細を見る
The effects of various concentrations of biogenic amines on the formation of adenosine-3', 5'-monophosphate (cyclic AMP) and their interactions with other thyroid stimulators were investigated in human thyroid slices from normal and Graves' disease. Most of biogenic amines were found to have the stimulatory effects to some extent. Among the biogenic amines tested, histamine was the most potent thyroid stimulator, norepinephrine and serotonin, the intermediate in terms of cyclic AMP formation. The effect of histamine was almost as potent as TSH in thyroid slices from Graves' disease. This stimulatory effect of histamine was blocked by metiamide, a histamine H<SUB>2</SUB>-receptor antagonist, but not by chlorpheniramine, a histamine H<SUB>1</SUB>-receptor antagonist. The effect of norepinephrine was completely inhibited by propranolol, but not by phentolamine. Polyphloretin phosphate did not inhibit norepinephrine-or histamine-induced cyclic AMP formation, while it significantly depressed cyclic AMP formation induced by prostaglandin E<SUB>2</SUB>. The maximal effect of histamine was additive to that of TSH. It is suggested that biogenic amines, histamine and norepinephrine, in particular, have the thyroid receptors different from that of TSH or prostaglandin E<SUB>2</SUB> and could play an important role in thyroid physiology.
- 社団法人 日本内分泌学会の論文
著者
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Miyakawa Makoto
Department Of Surgery Iida Municipal Hospital
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Furihata Rikio
Departments Of Surgery Shinshu University School Of Medicine
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Hashizume Kiyoshi
Department Of Aging Medicine And Geriatrics Institute On Aging And Adaptation Shinshu University Gra
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Sato Akira
Department Of Advanced Surgical Science And Technology Tohoku University
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MAKIUCHI MASAO
Department of Medicine, Institute of Adaptation Medicine, Shinshu University School of Medicine
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HASHIZUME KIYOSHI
Department of Medicine, Institute of Adaptation Medicine, Shinshu University School of Medicine
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ONAYA TOSHIMASA
Department of Medicine, Institute of Adaptation Medicine, Shinshu University School of Medicine
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MIYAKAWA MAKOTO
Department of Medicine, Institute of Adaptation Medicine, Shinshu University School of Medicine
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FURIHATA RIKIO
Department of Medicine, Institute of Adaptation Medicine, Shinshu University School of Medicine
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