Effects of ACTH and Calcium on Cyclic AMP Production and Steroid Output by the Zona Glomerulosa of the Adrenal Cortex
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概要
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Effects of ACTH and calcium on cyclic AMP production and steroid output by the zona glomerulosa (the capsular fraction) from the rat adrenal cortex have been studied. Although high concentrations of extracellular calcium potentiated the stimulatory action of ACTH on cyclic AMP and aldosterone output, tetracaine or verapamil inhibited aldosterone output but not cyclic AMP production during ACTH-stimulation. Lanthanum reduced both aldosterone and cyclic AMP accumulation induced by ACTH. These results suggest that an extracellular calcium would be essential in stimulating the capsular steroidogenesis without involvement of the cyclic AMP system.
- 社団法人 日本内分泌学会の論文
著者
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Shima Sumio
Department Of Biochemistry St.marianna University School Of Medicine
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Hirai Masanao
Department Of Pharmacology St. Marianna University School Of Medicine
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KAWASHIMA YOSHIKO
Department of Pharmacology, St. Marianna University School of Medicine, Kawasaki City
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KAWASHIMA Yoshiko
Department of Pharmacology, Jikei University School of Medicine
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SHIMA SUMIO
Department of Pharmacology, St. Marianna University School of Medicine, Kawasaki City
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