EFFECTS OF CHRONIC PROPRANOLOL TREATMENT ON HEPATIC ADENYLATE CYCLASE SYSTEM IN THE RAT.
スポンサーリンク
概要
- 論文の詳細を見る
The biochemical aspects of hepatic β-adrenergic receptors and adenylate cyclase activity in male adult rats were examined during chronic treatment of a β-adrenergic antagonist, propranolol. The blockade of β-adrenergic nervous systems for 7 to 10 days produced a considerable elevation of basal, glucagon, sodium fluoride, and 5′-guanylylimidodiphosphate, Gpp (NH)p-stimulated enzyme activity with a negligible response to a β-adrenergic agonist, isoproterenol. There was no alteration in the density or the affinity of β-adrenergic receptors for the agonist during the treatment. Guanine nucleotides have failed to induce a transformation of the higer affinity to the lower affinity state of β-adrenergic receptors of the hepatic membrane derived either from control or the propranolol-treated animals. The activity of stimulatory guanine nucleotide regulatory proteins (Ns)in the enzyme, assessed by ADP-ribosylation was also not altered by the antagonist. These results suggest that the mechanism of the observed sensitization of adenylate cyclase induced by chronic β-adrenergic blockade involves facilitation of Ns interaction with the catalytic subunit of the enzyme with no change in the β-adrenergic receptor functions.
- 日本トキシコロジー学会の論文
- 1987-08-25
著者
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AKAMATSU Nobu
Department of Biochemistry and First Department of Physiology, St. Marianna University School of Med
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Akamatsu N
St. Marianna Univ. School Of Medicine Kawasaki Jpn
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Akamatsu Nobu
Department Of Biochemistry And First Department Of Physiology St. Marianna University School Of Medi
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SHIMA Sumio
Department of Biochemistry, St.Marianna University School of Medicine
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OKEYAMA Naoko
Department of Biochemistry, St.Marianna University School of Medicine
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OIKAWA Shigeo
Department of Biochemistry, St.Marianna University School of Medicine
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Shima Sumio
Department Of Biochemistry St.marianna University School Of Medicine
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Okeyama Naoko
Department Of Biochemistry St.marianna University School Of Medicine
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Oikawa Shigeo
Department Of Biochemistry St.marianna University School Of Medicine
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