The Effect of Streptozotocin on the Pancreatic A Cell Function

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The effect of a single i. v. injection of30, 50, and65mg of streptozotocin (Sz) per kg of body weight on blood glucose, plasma insulin and glucagon levels was studied in rats. Responses to glucose of these three parameters were also examined in rats one week after the administration of various doses of Sz alone, Sz with nicotinamide or with picolinamide. Nicotinamide, 500mg/kg, and picolinamide, 250mg/kg, were given i.p. 15min before the injection of 65mg/kg of Sz.<BR>The triphasic pattern was observed after the injection of 65mg/kg of Sz not only in blood glucose and plasma insulin but also in plasma glucagon level fluctuations, the last of which showed a similar pattern to that of blood glucose responses. Further, the initial hyperglucagonemia had a delay of 2hr in onset, when treated with30and50mg/kg of Sz, respectively.<BR>Oral glucose loading resulted in a significant increase of plasma glucagon levels in rats injected with 30 and 50mg/kg of Sz, respectively. The paradoxical rise of plasma glucagon and glucose intolerance was observed in rats given Sz with nicotinamide, and Sz with picolinamide, as well as in those given Sz alone, 65mg/kg, while there was no significant difference in insulin responses between the pretreated groups of rats and controls.<BR>These results suggest that streptozotocin, even in a nondiabetogenic dose, has effect (s) on the A cell function, and that nicotinamide and picolinamide are active in protecting B cells against the cytotoxic effect, but they do not modify the effect of Sz on the A cell function.
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The Effect of Streptozotocin on the Pancreatic A Cell Function

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