Effect of Propranolol on Glucose-Induced Insulin Response in Rats with Insulinomas
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概要
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This paper describes an inhibitory effect of propranolol on insulin secretion in rats with pancreatic islet cell tumors which have been induced by streptozotocin (65mg/kg body weight) and nicotinamide (500mg/kg).<BR>Following glucose ingestion (3g/kg), propranolol (4mg/kg) was injected into the tumor-bearing rats. Plasma insulin decreased paradoxically despite an increase in blood glucoses. In contrast, propranolol did not suppress insulin secretion in normal rats. The drug was found to have no effect on glucagon secretion in either experimental or control animals during glucose load.<BR>This may suggest that the experimentally induced insulinoma is hypersensitive to propranolol for inhibiting insulin secretion.
- 社団法人 日本内分泌学会の論文
著者
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Baba Shigeaki
The Second Department Of Internal Medicine Kobe University School Of Medicine
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KAZUMI TSUTOMU
The Second Department of Internal Medicine, Kobe University School of Medicine
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YOSHINO GEN
The Second Department of Internal Medicine, Kobe University School of Medicine
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TERASHI KATSUHIRO
The Second Department of Internal Medicine, Kobe University School of Medicine
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KOBAYASHI NOBORU
The Second Department of Internal Medicine, Kobe University School of Medicine
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MORITA SOICHIRO
The Second Department of Internal Medicine, Kobe University School of Medicine
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YOSHINO GEN
The Second Department of Internal Medicine Kobe University School of Medicine
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KAZUMI TSUTOMU
The Second Department of Internal Medicine Kobe University School of Medicine
-
KOBAYASHI NOBORU
The Second Department of Internal Medicine Kobe University School of Medicine
-
TERASHI KATSUHIRO
The Second Department of Internal Medicine Kobe University School of Medicine
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MORITA SOICHIRO
The Second Department of Internal Medicine Kobe University School of Medicine
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