Increase of Pancreatic Somatostatin Concentration in Early Phases of Streptozotocin Diabetes in Rats
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概要
- 論文の詳細を見る
A small yet significant increase of immunoassayable pancreatic somatostatin concentration (0.107±0.005 vs. 0.156±0.017μg/g at 24hr, p<0.05) was found in rats, 24hr as well as 7 days after treatment with a diabetogenic dose of streptozotocin (65mg/kg BW). These animals were characterized by marked decreases of insulin in the pancreas without any significant changes in pancreatic glucagon concentration. These results suggest that an abrupt deprivation of insulin from islets results in an elevation of pancreatic somatostatin concentration, and that glucagon in the pancreas plays a minor role in determining pancreatic somatostatin concentration in rats with insulin-deprived diabetes of short duration.
- 社団法人 日本内分泌学会の論文
著者
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Baba Shigeaki
The Second Department Of Internal Medicine Kobe University School Of Medicine
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KAZUMI TSUTOMU
The Second Department of Internal Medicine, Kobe University School of Medicine
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UTSUMI MASAFUMI
The Second Department of Internal Medicine, Kobe University School of Medicine
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YOSHINO GEN
The Second Department of Internal Medicine, Kobe University School of Medicine
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TERASHI KATSUHIRO
The Second Department of Internal Medicine, Kobe University School of Medicine
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KOBAYASHI NOBORU
The Second Department of Internal Medicine, Kobe University School of Medicine
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ISHIHARA KAZUHIDE
The Second Department of Internal Medicine, Kobe University School of Medicine
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MAKIMURA HIROYUKI
The Second Department of Internal Medicine, Kobe University School of Medicine
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MORITA SOICHIRO
The Second Department of Internal Medicine, Kobe University School of Medicine
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YOSHINO GEN
The Second Department of Internal Medicine Kobe University School of Medicine
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KAZUMI TSUTOMU
The Second Department of Internal Medicine Kobe University School of Medicine
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KOBAYASHI NOBORU
The Second Department of Internal Medicine Kobe University School of Medicine
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TERASHI KATSUHIRO
The Second Department of Internal Medicine Kobe University School of Medicine
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MORITA SOICHIRO
The Second Department of Internal Medicine Kobe University School of Medicine
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