Werner Interacting Protein 1 Promotes Binding of Werner Protein to Template-Primer DNA
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概要
- 論文の詳細を見る
Werner interacting protein 1 (WRNIP1) that is highly conserved from Escherichia coli to human was originally identified as a protein that interacts with the Werner syndrome responsible gene product (WRN). Here, human WRNIP1 and WRN are shown to bind to template-primer DNA, and WRNIP1, but not WRN, requires ATP for DNA binding. Under conditions of a limiting amount of WRN, WRNIP1 facilitated binding of WRN to DNA in a dose-dependent manner. However, WRNIP1 did not stimulate the DNA helicase activity of WRN, and WRN displaced pre-bound WRNIP1 from DNA. Functional relationships between WRNIP1 and WRN will be discussed.
著者
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Seki Masayuki
Molecular Cell Biology Laboratory Graduate School Of Pharmaceutical Sciences Tohoku University
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Kanamori Makoto
Molecular Cell Biology Laboratory Graduate School Of Pharmaceutical Sciences Tohoku University
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Tsurimoto Toshiki
Department Of Biology Laboratory School Of Sciences Kyusyu University
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Seki M
Nissin Kogyo Co. Ltd. Tobu Jpn
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Yoshimura Akari
Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, Musashino University
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Tada Shusuke
Faculty of Pharmaceutical Sciences, Teikyo Heisei University
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Enomoto Takemi
Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy, Musashino University
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Tsurimoto Toshiki
Department of Biology Laboratory, School of Sciences, Kyushu University
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