Rad50 is involved in MMS-induced recombination between homologous chromosomes in mitotic cells
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概要
- 論文の詳細を見る
The structural maintenance of chromosomes (SMC) family proteins (Smc1-Smc6) typically consist of two coiled-coil domains, an amino-terminal head domain, and a carboxyl-terminal tail domain. Rad50, a component of the Mre11/Rad50/Xrs2 (MRX) complex, has a similar domain structure to the SMC proteins. In Saccharomyces cerevisiae, the MRX complex appears to be essential for recombination between homologous chromosomes in meiotic cells, but not in cells undergoing vegetative growth. Here we provide for the first time evidence that Rad50, like Smc6, is required for the induction of recombination between homologous chromosomes in cells in the vegetative growth state upon exposure to methyl methanesulfonate. However, UV-induced recombination between homologous chromosomes is intact in both rad50 and smc6-56 mutant cells.
- 日本遺伝学会の論文
- 2007-04-25
著者
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SEKI Masayuki
Molecular Cell Biology Laboratory, Graduate School of Pharmaceutical Sciences, Tohoku University
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UI Ayako
Molecular Cell Biology Laboratory, Graduate School of Pharmaceutical Sciences, Tohoku University
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ONODA Fumitoshi
Molecular Cell Biology Laboratory, Graduate School of Pharmaceutical Sciences, Tohoku University
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ENOMOTO Takemi
Molecular Cell Biology Laboratory, Graduate School of Pharmaceutical Sciences, Tohoku University
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Ui Ayako
Molecular Cell Biology Laboratory Graduate School Of Pharmaceutical Sciences Tohoku University
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Seki Masayuki
Molecular Cell Biology Laboratory Graduate School Of Pharmaceutical Sciences Tohoku University
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Enomoto Takemi
Molecular Cell Biology Laboratory Graduate School Of Pharmaceutical Sciences Tohoku University
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Enomoto T
Tohoku Univ. Miyagi
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Tada Shusuke
Molecular Cell Biology Laboratory Graduate School Of Pharmaceutical Sciences Tohoku University
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Onoda Fumitoshi
Molecular Cell Biology Laboratory Graduate School Of Pharmaceutical Sciences Tohoku University
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TOMIZAWA Yuji
Molecular Cell Biology Laboratory, Graduate School of Pharmaceutical Sciences, Tohoku University
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OGIWARA Hideaki
Molecular Cell Biology Laboratory, Graduate School of Pharmaceutical Sciences, Tohoku University
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Enomoto T
Molecular Cell Biology Laboratory Graduate School Of Pharmaceutical Sciences Tohoku University
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Enomoto Takemi
Cell Biology Laboratory Graduate School Of Pharmaceutical Sciences Tohoku University
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Seki M
Nissin Kogyo Co. Ltd. Tobu Jpn
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Tomizawa Yuji
Molecular Cell Biology Laboratory Graduate School Of Pharmaceutical Sciences Tohoku University
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Ogiwara Hideaki
Molecular Cell Biology Laboratory Graduate School Of Pharmaceutical Sciences Tohoku University
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