Physical and functional interaction between WRNIP1 and RAD18

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概要

• 論文の詳細を見る

• WRN interacting protein 1 (WRNIP1) was originally identified as a protein that interacts with the Werner syndrome responsible gene product (WRN). WRNIP1 is a highly conserved protein from E. coli to humans. Genetic studies in budding yeast suggested that the yeast orthlog of WRNIP1, Mgs1, may function in a DNA damage tolerance pathway that is similar to, but distinct from, the template-switch damage avoidance pathway involving Rad6, Rad18, Rad5, Mms2, and Ubc13. Here we report that human WRNIP1 binds in an ATP dependent manner to both forked DNA that mimics stalled replication forks and to template/primer DNA. We found that WRNIP1 interacts physically with RAD18 and interferes with the binding of RAD18 to forked DNA and to template/primer DNA. In contrast, RAD18 enhances the binding of WRNIP1 to these DNAs, suggesting that WRNIP1 targets DNA bound by RAD18.

• 日本遺伝学会の論文
• 2009-04-25

著者

• SEKI Masayuki

  Molecular Cell Biology Laboratory, Graduate School of Pharmaceutical Sciences, Tohoku University

• ENOMOTO Takemi

  Molecular Cell Biology Laboratory, Graduate School of Pharmaceutical Sciences, Tohoku University

• Seki Masayuki

  Molecular Cell Biology Laboratory Graduate School Of Pharmaceutical Sciences Tohoku University

• Enomoto Takemi

  Molecular Cell Biology Laboratory Graduate School Of Pharmaceutical Sciences Tohoku University

• Enomoto T

  Tohoku Univ. Miyagi

• Tada Shusuke

  Molecular Cell Biology Laboratory Graduate School Of Pharmaceutical Sciences Tohoku University

• YOSHIMURA Akari

  Molecular Cell Biology Laboratory, Graduate School of Pharmaceutical Sciences, Tohoku University

• Tateishi Satoshi

  Cell Genetics Institute Of Molecular Embryology And Genetics Kumamoto University

• Enomoto T

  Molecular Cell Biology Laboratory Graduate School Of Pharmaceutical Sciences Tohoku University

• Enomoto Takemi

  Cell Biology Laboratory Graduate School Of Pharmaceutical Sciences Tohoku University

• KANAMORI Makoto

  Molecular Cell Biology Laboratory, Graduate School of Pharmaceutical Sciences, Tohoku University

• TSURIMOTO Toshiki

  Department of Biology Laboratory, School of Sciences, Kyusyu University

• Kanamori Makoto

  Molecular Cell Biology Laboratory Graduate School Of Pharmaceutical Sciences Tohoku University

• Tsurimoto Toshiki

  Department Of Biology Laboratory School Of Sciences Kyusyu University

• Seki M

  Nissin Kogyo Co. Ltd. Tobu Jpn

• Yoshimura Akari

  Molecular Cell Biology Laboratory Graduate School Of Pharmaceutical Sciences Tohoku University

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