海産ジテルペノイドsanadaolの全合成
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概要
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The first total synthesis of (±) -sanadaol, structurally unique marine diterpene isolated from brown algae <I>Pachydictyon coriaceum</I> and <I>Dictyota crenulata</I>, is described. The key step of this fully stereocontrolled synthesis involves the fragmentation reaction of tricyclic compound 21 forming bicyclic compound 22 having suitably functionalised framework of sanadaol. Further, both (-) - and (+) -sanadaol were synthesized stereoselectively from D-mannitol <I>via</I> chiral bicyclo [2.2.2] octane derivative 47. This accomplishment determined the absolute configuration of sanadaol and that of dictyodial as shown in (+) -1 and 59, respectively.
- 社団法人 有機合成化学協会の論文
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